![]() ![]() The BMJ commissioned, peer reviewed, edited, and made the decision to publish. This article is part of a collection funded by the special purpose funds for the belt and road, China Academy of Chinese Medical Sciences, National Natural Science Foundation of China, the National Center for Complementary and Integrative Health, the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine, the Special Project of “Lingnan Modernization of Traditional Chinese Medicine” of the 2019 Guangdong Key Research and Development Program, and the Project of First Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine. T1 - Increasing the usefulness of acupuncture guideline recommendations The funders had no influence on study design, data collection, analysis, decision to publish, or manuscript preparation.", Funding Information: Competing interests: We have read and understood BMJ policy on declaration of interests and declare that the study was supported by the special project of “Lingnan Modernization of Traditional Chinese Medicine” within the 2019 Guangdong Provincial Research and Development Program (2020B1111100008) the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202004) and the National Natural Science Foundation of China (82174527). Gordon Guyatt provided valuable advice and guidance. Yu-Qing Zhang advised on commissioning for the collection, designed the topic of the series, and coordinated the author teams. Kamran Abbasi was the lead editor for The BMJ. ![]() ![]() All rights reserved.Note = "Funding Information: This article is part of a collection funded by the special purpose funds for the belt and road, China Academy of Chinese Medical Sciences, National Natural Science Foundation of China, the National Center for Complementary and Integrative Health, the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine, the Special Project of “Lingnan Modernization of Traditional Chinese Medicine” of the 2019 Guangdong Key Research and Development Program, and the Project of First Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine. In conclusion, our study reveals that exosomes mediate a horizontal transfer of drug-resistant trait in chronic myeloid leukemia cell by delivering miR-365.Ĭhemosensitivity Chronic myeloid leukemia Exosomes MiR-365.Ĭopyright © 2017 Elsevier Inc. We further confirmed that exosomal transfer of miR-365 induced drug resistance by inhibiting expression of pro-apoptosis protein in sensitive CML cells. The imatinib sensitive CML cells transfected with pre-miR-365 displayed lower chemosensitivity and apoptosis rate compared with controls. ![]() We also demonstrated a significant higher level of miR-365 in exosomes derived from drug-resistant CML cells compared with those from sensitive ones using microarray and qRT-PCR. Herein, we found that exosomes derived from imatinib resistant CML cells can be internalized into sensitive CML cells and confer drug-resistance traits. Accumulated evidences have identified exosomes in cancer as promoters of tumor progression. Majority of patients can be effectively treated with tyrosine kinase inhibitors (TKIs) such as imatinib, but a portion of patients will develop drug resistance. Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem/progenitor cells. ![]()
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